Journal Basic Info
- Impact Factor: 1.809**
- H-Index: 6
- ISSN: 2474-1655
- DOI: 10.25107/2474-1655
Major Scope
- Radiology Cases
- Nuclear Medicine
- Pediatrics
- Endocrinology
- Inflammation
- Signs and Symptoms-Clinical Findings
- Breast Neoplasms
- Sleep Medicine and Disorders
Abstract
Citation: Ann Clin Case Rep. 2019;4(1):1664.DOI: 10.25107/2474-1655.1664
Diagnosis of Cushing Syndrome during an Infertility Evaluation
Amanda R Schwartz, Lauren Gratian and Thomas M Price
1Department of Obstetrics and Gynecology, Duke University, USA
Department of Internal Medicine, Duke University, USA
*Correspondance to: Thomas M Price
PDF Full Text Clinical Video | Open Access
Abstract:
Many cases of Cushing’s disease or syndrome are diagnosed after progression of initial non-specific symptoms including weight gain, hirsutism, mood changes and hypertension. In this unusual case, abnormality of the cortisol axis was considered after finding a low level of the adrenal androgen precursor, dehydroepiandrosterone sulfate, during an infertility evaluation for anovulation. Low dehydroepiandrosterone sulfate proved secondary to decreased pituitary adrenocorticotropin hormone production from hypercortisolism associated with an adrenal adenoma. Although dehydroepiandrosterone sulfate levels naturally decline with aging, abnormally low levels should raise suspicion for Cushing’s syndrome.
Keywords:
Cushing’s syndrome; Infertility; Ovulatory dysfunction; Amenorrhea; Dehydroepiandrosterone sulfate
Cite the Article:
Schwartz AR, Gratian L, Price TM. Diagnosis of Cushing Syndrome during an Infertility Evaluation. Ann Clin Case Rep. 2019; 4: 1664.
