Therapeutic Iron Infusion Causing Delayed Venous Contamination in Magnetic Resonance Angiography

Wei Li, Ioannis Koktzoglou, Eugene Dunkle and Robert R Edelman

Department of Radiology, North Shore University Health System, USA

^*Correspondance to: Wei Li 

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Abstract:

The diagnostic quality of magnetic resonance angiography (MRA) depends on the reliable suppression of venous signal, which otherwise overlaps arterial signal. In the case presented here, the quality of non-enhanced MRA was severely contaminated by venous signal due to a therapeutic iron infusion (ferumoxytol, intravascular half-life ~15 hours) two days prior to the MRA exam. The cause of the venous contamination was that intravenously injected ferumoxytol substantially shortened the longitudinal relaxation time (T1) of the blood, so that venous presaturation no longer was effective. This case highlights the importance of considering prior iron infusion as a cause of MRA artifacts and including it in the pre-exam questionnaire.

Keywords:

Enhanced MRA; Venous contamination; Feraheme; Ferumoxytol; Iron

Cite the Article:

Li W, Koktzoglou I, Dunkle E, Edelman RR. Therapeutic Iron Infusion Causing Delayed Venous Contamination in Magnetic Resonance Angiography. Ann Clin Case Rep. 2018; 3: 1497.