Contralateral Crossrecurrence of a Malignant Glioma: A Case With Long-Term Survival

S Ferraresi, E Brognaro, G Pavanato and MR Ballotta

Department of Neurosurgery, Ospedale S.Maria della Misericordia, Italy
Department of Radiotherapy, Ospedale S.Maria della Misericordia, Italy
Department of Pathology, Ospedale S.Maria della Misericordia, Italy

^*Correspondance to: S Ferraresi 

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Abstract:

In surgically treated glioblastomas a recurrence of the primitive tumour with subsequent infiltration of the surrounding parenchyma is the commonest cause of death. In the vast majority of the cases it occurswithin or nearby thetumour site. However, in a few patients the recurrence is locatedfar from the primary tumor site and radiological heralding signs may even not be visible. This paper illustrates the clinical and radiological patterns of a 56 year old woman with a right occipital glioblastoma and a late contralateral cross recurrence in the left frontal lobe. After a complete surgical removal, the patient experienced an high quality 6 year-survival period. The tumour was expressing the promoter to methylation but was wild type for IDH mutation. It was treated with radiotherapy plus Temozolamide. Lately she developed a very unusual contralateral cross-recurrence with these cond tumour genetically similar to the original one (MGMT promoter and IDH wild type) but rapidly and relentlessly fatal. As a peculiar event we have an MRI, incourse of a routine control done 4 months before the second hospitalization, which shows no sign of recurrence. This casts a further light on the speed and modality of growth of an high grade glioma.

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Cite the Article:

S Ferraresi, E Brognaro, G Pavanato, MR Ballotta. Contralateral Crossrecurrence of a Malignant Glioma: A Case With Long-Term Survival. Ann Clin Case Rep. 2017; 2: 1390.