Challenges in Diagnosing Permature Ovarian Failure

Holly George and Mourad W Seif

Department of Obstetrics and Gynecology, St. Marys Hospital, UK

^*Correspondance to: Mourad W. Seif 

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Abstract:

This is a case report of a single, 25 year old female of Asian origin, who was referred to the reproductive endocrinology clinic at St. Marys Hospital, Manchester with the initial diagnosis of Premature Ovarian Failure (POF) for manging her hormone replacement therapy. She had a complex medical history including a cerebellar pilocytic astrocytoma, excised at the age of 3, with supplementary radiotherapy. The diagnosis of POF was made at the age of 16 following history and investigation, primarily on the basis of amenorrhoea and low serum oestradiol levels. Hormonal profile was revisited and genital tract imaging was undertaken. The revised diagnosis of hypothalamic amenorrhoea had been overlooked which had major implications on future fertility. The principles of diagnostics and therapeutic measure are discussed.

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Cite the Article:

George H, Seif MW. Challenges in Diagnosing Permature Ovarian Failure. Ann Clin Case Rep. 2017; 2: 1276.