Myoepithelial Carcinoma of the Nasal Cavity: A Case Report

Jeong-Hwa Kwon, Min Jeong Song, Joon Seon Song, Seung-Ho Choi and Kyung-Ja Cho

Departments of Pathology, University of Ulsan College of Medicine, Korea
Departments of Otorhinolaryngology, University of Ulsan College of Medicine, Korea

^*Correspondance to: Kyung-Ja Cho 

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Abstract:

Background: Myoepithelial carcinoma is a rare epithelial tumor typically originates in the salivary gland tissues. We report a case of myoepithelial carcinoma arising in nasal cavity.Methods: A 53-year-old man presented with a 2-month history of symptoms of nasal obstruction and epistaxis. Computed tomography revealed an enhancing mass occupying entire left nasal cavity, with obstructive sinusitis in paranasal sinuses. Medial maxillectomy was performed.Results: Microscopic analysis revealed multi nodular tumor with solid, reticular, trabecular, and pseudoacinar growth patterns. Tumor cells were monomorphic round to oval cells, with eosinophilic cytoplasm and round hyperchromatic nuclei. Clear cells were rare. The tumor cells showed diffuse immunoreactivity for calponin, smooth muscle actin, p40 and p63, and immuno negativity for PLAG1. Electron microscopy demonstrated intracytoplasmic myofilaments in tumor cells. The tumor did not harbor EWSR1 gene rearrangement by break-apart FISH.Conclusion: This is an additional rare case of sinonasal myoepithelial carcinoma, especially with ultrastructural and molecular study.

Keywords:

Myoepithelial carcinoma; Malignant; Nasal cavity; Sinonasal

Cite the Article:

Kwon J-H, Song MJ, Song JS, Choi S-H, Cho K-J. Myoepithelial Carcinoma of the Nasal Cavity: A Case Report. Ann Clin Case Rep. 2017; 2: 1237.