Journal Basic Info

  • Impact Factor: 1.809**
  • H-Index: 6
  • ISSN: 2474-1655
  • DOI: 10.25107/2474-1655
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Nephrology
  •  Breast Neoplasms
  •  Medical Radiography
  •  Nursing
  •  Forensic and Legal Medicine
  •  Pathology
  •  Child Birth
  •  Obstetrics and Gynecology


Citation: Ann Clin Case Rep. 2016;1(1):1012.DOI: 10.25107/2474-1655.1012

Isolated Hemi-hyperplasia

Dinesh Singh, Ocheowelle Okeke, Lea D Seeber and Olugbenga Akingbola

Department of Pediatrics, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, 70112, Louisiana, USA

*Correspondance to: Dinesh Singh 

 PDF  Full Text Clinical Image | Open Access


6-month old male presented with macrocephaly (progressive), macrosomia, macroglossia, splenomegaly, and left-sided hemi-hypertrophy. Magnetic Resonance Imaging showed large left cerebral hemisphere and hydrocephalus with normal fourth ventricle consistent with aqueductal stenosis. There was no evidence of any lipomas or hemangiomas. There was no family history of hemi-hypertrophy. Microarray based comparative genome hybridization and chromosome analyses were negative. Workup for Beckwith-Wiedemann syndrome (BWS), Neurofibromatosis, and PTEN hamartoma tumor syndromes (PHTS) was negative. A diagnosis of Isolated Hemi-hyperplasia was made which is characterized by asymmetric overgrowth of one or more regions of the body secondary to abnormal cell proliferation with an estimated incidence of 1 in 86,000. It is associated with seizures, undescended testes, inguinal hernia, communicating hydrocephalus, bicuspid aortic valve, cushing syndrome and increased risk of embryonal tumors particularly wilm’s tumor. It is proposed to be part of the spectrum of phenotypes of BWS, which maps to 11p15.5.


Cite the Article:

Singh D, Okeke O, Seeber LD, Akingbola O. Isolated Hemihyperplasia. Ann Clin Case Rep. 2016; 1: 1012.

Search Our Journal

Journal Indexed In

Articles in PubMed

Tocotrienols: Exciting Biological and Pharmacological Properties of Tocotrienols and other Naturally Occurring Compounds, Part I
 PubMed  PMC  PDF  Full Text
Does Autoimmunity have a Role in Myoclonic Astatic Epilepsy? A Case Report of Voltage Gated Potassium Channel Mediated Seizures
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Acute Monocytic Leukemia Secondary to Angioimmunoblastic T-Cell Lymphoma: A Case Report and Literature Review
 Abstract  PDF  Full Text
Traditional Chinese Patent Medicine Qizhijiangtang Capsule for Non-Proliferative Diabetic Retinopathy: Study Protocol for a Randomized Controlled Trial
 Abstract  PDF  Full Text
View More...