Case Report
Sciatic Neuropathy and Hypogammaglobulinemia Common Disorder with Uncommon Cause
Ioannidis P, Parissis D, Boziki M, Natsis KS* and Karacostas D
Department of Neurology, AHEPA University Hospital, Greece
*Corresponding author: Natsis S. Konstantinos, Department of Neurology, AHEPA University Hospital, St. Kyriakidi 1, 54636, Thessaloniki, Greece
Published: 11 Aug, 2016
Cite this article as: Ioannidis P, Parissis D, Boziki M, Natsis
KS, Karacostas D. Sciatic Neuropathy
and Hypogammaglobulinemia Common
Disorder with Uncommon Cause. Ann
Clin Case Rep. 2016; 1: 1062.
Abstract
Hypogammaglobulinemia has rarely been linked with neuropathy. We report a case of a young female who presented with foot drop due to sciatic neuropathy in the context of hypogammaglobulinemia and had significant clinical improvement after intravenous immunoglobulin (IVIG) treatment. To our knowledge, this is the second report that manifests evidence of immune-mediated neuropathy in the presence of hypogammaglobulinemia.
Keywords: Sciatic; Neuropathy; Hypogammaglobulinemia; Common variable immunodeficiency; Intravenous immunoglobulin (IVIG) treatment
Case Report
A 15-year old female was referred for evaluation of a left foot drop and left lower limb muscle
weakness. The symptoms had reportedly started 1 year ago, evolved over few weeks and were further
accompanied with left plantar dysaesthesia and numbness, gradually including the posterior - outer
part of the left calf.
Personal history included frequent episodes since infancy with fever, gastrointestinal infections
and bronchitis, as well as recurrent ear infections and tonsillitis. At the age of 4 she underwent
tonsillectomy and adenoidectomy. She also suffered from frequent urethritis, pharyngitis
and skin infections. At the age of 7, laboratory investigation showed combined IgA and IgG
hypogammaglobulinemia while the rest of the investigation was reported to be within normal limits
(common variable immunodeficiency - CVID). The patient received immunoglobulin replacement
therapy (0.5gr/kg/month) over a period of 6 years. During treatment she remained free of infections
and all immunoglobulin class values returned to normal range.
Upon neurological examination on admission the patient exhibited reduced left ankle reflex,
reduced muscle strength on knee flexion (4/5), plantar flexion (4/5) and dorsiflexion (2/5). There
was reduced sensation of the dorsal surface of the foot and the outer surface of the calf. The rest
neurological examination was normal. Serology including CRP, ESR and serum albumin and CSF
examination including screening for viruses, showed normal findings, however, reduced IgG (684
mg/dl, reference range 751-1560) as well as increased IgE (289 mg/dl, reference range 10-100) were
found. Serum free kappa chains was also reduced (471 mg/dl, reference range 629-1350).
Nerve conduction studies showed total absence of the left sural and superficial peroneal
nerve action potentials. The compound muscle action potentials of the left common peroneal and
posterior tibial nerve were severely reduced indicating substantial axonal loss. A mild prolongation
of the distal motor latencies, as well as a minor slowing of motor nerve conduction velocities in the
above nerves, were consistent with the degree of axonal loss. Electromyographic sampling showed
severe denervation confined to the territory of the left sciatic nerve. MRI examination of the pelviships
revealed thickening of the left sciatic nerve (Figure 1).
The patient was treated with a 5 days course of intravenous immunoglobulin (IVIG), followed by
a monthly single injection. After 3 months she had significant improvement regarding dysaesthesia
and walking difficulty. Muscle strength increased on knee flexion (5/5), as well as on plantar flexion
(5/5) and dorsiflexion (4/5).
Figure 1
Figure 1
MRI of the hips shows significant thickening of the left sciatic nerve (arrows). Right sciatic nerve appears normal on T1 TIRM coronal image.
Discussion
Hypogammaglobulinemia has rarely been linked with neuropathy [1-3]. To our knowledge, this is the second report that manifests evidence of immune-mediated neuropathy in the presence of
hypogammaglobulinemia [4].
In a series of pediatric patients with sciatic neuropathy based on etiology, the most frequent cause was structural stress of the nerve, either due to trauma, operational procedures or prolonged compression / immobilization [5]. Less prominent causes include tumor and vascular events, whereas in a small number of patients the neuropathy was idiopathic. Interestingly, in 3 patients the etiology was unknown, but symptoms’ precipitation was attributed to viral infection.
Given the fact that our patient did not report previous trauma or operation on the pelvic area, traumatic etiology of sciatic neuropathy was considered unlikely. Based on the previous history of the patient, the subacute onset of symptoms and the impressive response to IVIG treatment, we consider the immune mediated mechanism (possibly autoimmunity) as the most likely scenario.
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