Dong S1, Sun M1, Chen C1, Wang J2, Jin Q3 and Cheng H1*
1Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, China
2Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, China
3Department of Neurology, The Affiliated Sir Run Run Hospital of Nanjing Medical University, China
Autoimmune nodopathy with Neurofascin-186 (NF-186) antibody positive is rare to report. This case report describes a patient with NF-186 antibody positive. This patient suffered from recurrent unclear speech accompanied by dysphagia. Hormone therapy was effective initially. But one month later, he experienced worsening speech and difficulties in swallowing, chewing, and moving his head. Further examination showed that both serum and cerebrospinal fluid anti-NF186 IgG antibody tests were positive. The patient again received hormone treatment, but this time it was ineffective. Subsequently, he received plasma exchange therapy, all neurological impairments improved significantly.
Dong S, Sun M, Chen C, Wang J, Jin Q, Cheng H. Cranial Nerve Injury and Neuropathy Around the Nodes of Ranvier with Positive Anti-NF186 Antibody: A Case Report. Ann Clin Case Rep. 2022; 7: 2334.