Revanth VSS Challa*, Vishwanath Krishnamurthy and Maheswari E
Department of Medicine, M S Ramaiah Medical College & Hospital, IndiaFulltext PDF
A wide variety of drugs and other chemical substances possessing a therapeutic value can induce either a transient or persistent elevations in the blood pressure, besides this also interact with some of the blood pressure lowering drugs hence reducing their efficacy. Some involve in sodium water retention and the others activate the sympathetic nervous system either directly or indirectly, however the drugs which induce elevations in the blood pressure levels involving the arteriolar smooth muscle do not have an established mechanism of action. However, some of the other classic anti-hypertensive also involve in elevating the blood pressure levels after discontinuation (rebound hypertension) is still a paradoxical effect. In majority of the cases the elevations in the blood pressure levels are for a short period and is predominantly transient some also involve in complications including stroke, encephalopathy, and renal failure etc. the fatal effects are more prominent among pre-hypertensive. Hence it is very important to evaluate use of any other concomitant medication and identifying the drug involved in elevating the blood pressure levels thereby avoiding the unnecessary initiation of anti-hypertensive regimen. Once the drug involved is identified it is usually discontinued or dose adjusted in cases where its use is obligatory. The present case summarizes the therapeutic agents or chemical substances that elevate blood pressure and their mechanisms of action.
Challa RVSS, Krishnamurthy V, Maheswari E. Unusual Case of Elevated Blood Pressure - A Case Report. Ann Clin Case Rep. 2022; 7: 2267..