Ann Clin Case Rep | Volume 7, Issue 1 | Case Report | Open Access

Herpes Zoster Ophthalmicus Reactivation after mRNA 1273 Vaccination

Ashraful Hoque1* and Hossain Imam2

1Department of Blood Transfusion, Sheikh Hasina National Institute of Burn & Plastic Surgery, Bangladesh 2Department of Burn & Plastic Surgery, Sheikh Hasina National Institute of Burn & Plastic Surgery, Bangladesh

*Correspondance to: Ashraful Hoque 

Fulltext PDF


Background: Clinically two different types of Varicella-Zoster Virus (VZV) infection are found commonly. Varicella (chickenpox) is caused by primary infection, and Herpes zoster, also known as shingles, is caused by reactivation of latent VZV that gained access to sensory ganglia during varicella. Reactivation is influenced by age-related immune-senescence, iatrogenic immunosuppression or disease-related immune-compromise state. As a vaccine can cause Immune Reconstitution Inflammatory Syndrome (IRIS), it can also reactivate VZS. Case Report: We discovered an elderly male (62 years old, Bangladeshi) with a painful blister around his right eyeball, as well as blurred vision in that eye. Examination found decreased visual acuity with hyperemia and edema in the eyelid and conjunctiva. He was found to have Herpes Zoster Ophthalmicus (HZO). Herpes zoster is a reactivation of the varicella-zoster virus, most commonly seen in the elderly and immunosuppressed, with incidence estimates ranging from 1.25 to 5.25 per 1,000 person-years showed in different studies. If patients are not treated promptly and aggressively, HZO with intraocular involvement can significantly impair visual vision. Our patient recovered entirely after getting proper treatment. Conclusion: No vaccine is 100% safe, and intense surveillance to assess the vaccine safety for the detection of any event which could attenuate the expected benefits, and thus to take any necessary action to minimize risks to vaccinated individuals.


Reactivation; Herpes Zoster Ophthalmicus; Immunocompromised; Vaccine


Hoque A, Imam H. Herpes Zoster Ophthalmicus Reactivation after mRNA 1273 Vaccination. Ann Clin Case Rep. 2022; 7: 2224..

Subscribe to Our Newsletter