1SoET, Purdue University, West Lafayette, USA 2CBST, Vellore Institute of Technology, Vellore, IndiaFulltext PDF
Proteomics is the study of the large set of proteins expressed by an organelle, a cell, a tissue, a liquid at a given time and condition. Clinical proteomics is the application of proteomics for clinical samples, such as blood, urine, serum and other. Since protein is the basic, fundamental unit of cell functions, its characteristics and pathways, study of clinical proteomics is of practical interest, relevance, and importance. Clinical proteomics is mostly applied in cancer samples and studies on cardiac, COVID-19, and other disease are also on the way, leading to the identification of novel biomarkers and targets, enabling better clinical treatment to the patients. Clinical proteomics also enables personalized/precision medicine by studying the characteristic attributes of the patient under concern. Of course, application of proteomics to clinical practice also comes with its challenges on standardization of the sample collection (such as amount, time duration, etc.), validation of the results, and other. In this mini-review, the various clinical applications of proteomics are discussed, to illustrate the potential of this powerful technique. The challenges and potential future needs are also indicated.
Clinical proteomics; Cancer; Biomarker; Mass spectrometry
Sundararajan R. Clinical Applications of Proteomics: Another Look. Ann Clin Case Rep. 2022; 7: 2213..