Josip Juraj Strossmayer University of Osijek, CroatiaFulltext PDF
It seems that the four authorized SARS-CoV-2 vaccines can induce symptoms that resemble some common COVID-19 symptoms; this article is looking whether exceptionally rare events after SARSCoV- 2 vaccines resemble rare COVID-19 complications. In searching for evidence in favor of this interpretation, COVID-19 vaccine safety updates by European Medicines Agency were used. It turned out that most recognized vaccine-related events can be linked to regulation of local tissue perfusion (myocarditis/pericarditis, capillary-leak syndrome) or coagulation. Similar rare complications were observed during COVID-19. The matching between rare disease complications and extremely rare vaccine linked events supports the notion that in very few persons, vaccination can resemble COVID-19 complications. An interpretation is proposed that due to preexistent circulatory dependence on balanced RAS actions in some persons, vaccination can lead to ACE2 dysfunctions downstream from areas of spike protein synthesis. Lungs and the heart muscle are mostly exposed to this scenario due to their central position in circulation that allows them to act as one self-regulatory unit. Different tropisms of used viral vectors and the variable fate of lipid nanoparticles in the four authorized vaccines can possibly explain differences in rare vaccine-related events.
COVID-19 complications; SARS-CoV-2 vaccines; vaccine related events; ACE2
Kurbel S. Some Events Linked to SARS-CoV-2 Vaccines Resemble Rare Complications of COVID-19: Are These Events Caused by Spike Protein Binding to ACE2 in Downstream Tissues with Preexisting Dependence on Balanced RAS Actions?. Ann Clin Case Rep. 2022; 7: 2150..