Schuler A1*, Omlin A1, Husarik D2, Denecke B1 and Rothermundt C1
1Department of Medical Oncology and Hematology, Cantonal Hospital St. Gallen, Switzerland 2Department of Radiology and Nuclear Medicine, Cantonal Hospital St. Gallen, SwitzerlandFulltext PDF
About 4% to 8% of patients with metastatic Colorectal Cancer (CRC) harbor deficient Mismatch Repair proteins (dMMR) and/or high Microsatellite Instability (MSI-H). We present the case of a patient with somatic dMMR (loss of MLH1 and PMS2), MSI-Hand BRAF V-600E mutated metastatic right-sided colon cancer treated with an Immune Checkpoint Inhibitor (ICI), who had radiological signs of Hyperprogressive Disease (HPD) with also an increase in tumour marker levels, followed by a Complete Remission (CR).
Colorectal cancer; Hyperprogression; Immune checkpoint inhibitor therapy; Microsatellite instability; Pseudoprogression
Schuler A, Omlin A, Husarik D, Denecke B, Rothermundt C. Hyper- or Pseudoprogression? A Case Report of MSI-High Metastatic Colorectal Cancer. Ann Clin Case Rep. 2021; 6: 2054..