Appearance of Ellagic Acid Metabolites from Pomegranate Juice in Breast Milk: A Case Report

Susanne M Henning, Matthew Ben Wallenstein, Nicole Weigel, Christine Johnson, Jieping Yang, Ru-Po Lee, Michelle Korn, Melissa Scala, David Stevenson K, Dina Ben-Nissan, David Heber and Zhaoping Li

Department of Medicine, Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, USA Department of Pediatrics, Stanford Medical Center, USA

^*Correspondance to: Dina Ben-Nissan 

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Abstract:

Pomegranate Juice (PomJ) contains Ellagitannins (ETs), the largest known group of polyphenol antioxidants with greater antioxidant activity than red wine or green tea. Maternal polyphenol consumption benefitting infant health could lead to greater incentive to breastfeed. In order to demonstrate the presence of EA metabolites in breast milk after consumption of PomJ, two healthy women with full-term, exclusively breast-fed infants, consumed 8 ounces of PomJ daily for two weeks. Breast milk and urine samples obtained on day 1, 7 and 14. Samples analyzed with Liquid Chromatography-Mass Spectrometry (LC-MS/MS) to identify EA metabolites. As a result, mothers had detectable and comparable EA metabolites (DMEAG and UAG) after 14 days of PomJ consumption. This pilot study demonstrates the presence of EA metabolites in breast milk after consumption of PomJ. Delivering phenolic compounds via breast milk could be a way to promote infant health and development.

Keywords:

Ellagic acid metabolites; Pomegranate juice; Breastfeeding; Breast milk; Antioxidant; Polyphenols

Cite the Article:

Henning SM, Wallenstein MB, Weigel N, Johnson C, Yang J, Lee R-P, et al. Appearance of Ellagic Acid Metabolites from Pomegranate Juice in Breast Milk: A Case Report. Ann Clin Case Rep. 2019; 4: 1738..