John Ogunkeye BA*, Brijesh Patel, Laurence Levine and Christopher Coogan
Department of Urology, Rush University Medical Center, USAFulltext PDF
Leydig Cell Tumors (LCTs) are rare neoplasms that account for only 5% of all testicular cancers. Although frequently asymptomatic, LCTs commonly present as precocious puberty in young children or endocrine abnormalities in adults between 30 and 60 years old. Endocrine changes are related to the hormonally active nature of Leydig cells, which are responsible for producing androgens. Standard treatment for LCTs is a radical orchiectomy, and after resection, LCTs are diagnosed through histopathological identification of their characteristic eosinophilic cytoplasm and Reinke crystal inclusion bodies. We report an atypical case of a benign LCT in a 26-year-old man with azoospermia and hypogonadism.
John Ogunkeye BA, Patel B, Levine L, Coogan C. Leydig Cell Tumor of the Testis, Presenting with Hypogonadism and Azoospermia. Ann Clin Case Rep. 2018; 3: 1554.