Ann Clin Case Rep | Volume 3, Issue 1 | Case Report | Open Access

Non-Hodgkin Lymphoma Simulating Carcinoma of the Vulvar Region: Report of Two Cases

Duenas Daniela^1*, Enriquez Daniel², Taxa Luis¹, Webb Patricia¹, Montes Jaime¹ and Barrionuevo Carlos¹

¹Department of Pathology, Instituto Nacional de Enfermedades Neoplásicas, Peru
²Department of Oncology, Instituto Nacional de Enfermedades Neoplásicas, Peru

^*Correspondance to: Duenas Daniela 

Abstract

Two cases of primary non-Hodgkin lymphoma of the vulva are reported. The first one corresponded to an 82-year old woman who showed a 6-cm vulvar injury with a multinodular appearance, whose pathological diagnosis was diffuse large-cell lymphoma B, germinal center B-cell type. She received R-MiniCHOP treatment for three months with partial response. The patient did not return for clinical monitoring in the end.The second case corresponded to a 35-year old woman showing an extensive vulvar ulcerated injury of 10 cm with pathological diagnosis of extranodal NK/T-cell lymphoma, nasal type with T-cell cytotoxic phenotype (EBER+), with CD56 expression and loss of CD8 expression. The T phenotype was determined by the study of genetic rearrangements for the T-cell receptor, which was monoclonal. The patient received the SMILE and GELOX treatments with low response and disease progression.Differential diagnosis is discussed, and the literature is reviewed regarding non-Hodgkin's lymphomas of the female genital tract.

Keywords:

Vulvar region; Diffuse large B-cell lymphoma; Extranodal NK/T-cell; Nasal type; Non-Hodgkin lymphoma; EBER

Citation:

Daniela D, Daniel E, Luis T, Patricia W, Jaime M, Carlos B. Non-Hodgkin Lymphoma Simulating Carcinoma of the Vulvar Region: Report of Two Cases. Ann Clin Case Rep. 2018; 3: 1547.