Ann Clin Case Rep | Volume 2, Issue 1 | Case Report | Open Access

Eosinophilic Pustular Folliculitis of Infancy

Lisa N. Isbouts1, Elske H. Weber1, Marleen Veenstra2 and Mathijs Binkhorst1*

1Department of Neonatology, Radboud University Medical Centre Amalia Children’s Hospital, Nijmegen, The Netherlands
2Department of Dermatology, Radboud University Medical Centre, Nijmegen, The Netherlands

*Correspondance to: Mathijs Binkhorst 

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Eosinophilic pustular folliculitis (EPF) is a rare, idiopathic, recurrent, self-limiting disease. It presents as sterile papulopustules located on the scalp and sometimes also on other body parts, without signs of systemic illness. Ten percent of cases occur in infants, mainly before the age of 6 months. The etiology is unknown. Eosinophilic pustular folliculitis of infancy (EPFI) is often underdiagnosed and overtreated, especially in a vulnerable population like preterm infants. We present a female neonate, born prematurely at a gestational age of 25 weeks. She developed recurrent papulopustules on an erythematous base with crustae. After initial treatment with antibiotics and antifungal agents, she was diagnosed with EPFI. We discuss the differential diagnosis and management of EPFI and its possible relationship with the immunological immaturity associated with preterm birth.


Eosinophilic pustular folliculitis; Newborn; Infant; Premature; Hyper-IgE syndrome


Isbouts LN, Weber EH, Veenstra M, Binkhorst M. Eosinophilic Pustular Folliculitis of Infancy. Ann Clin Case Rep. 2017; 2: 1483.

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