Erin Shiv*, Jessica Shank, John Richard, Monica Lutgendorf, Salewa Oseni and Preston Gable
Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Naval Medical Center San Diego, USAFulltext PDF
Background: We present the case of a woman previously treated with surgery, adjuvant chemotherapy and radiation who was diagnosed with recurrent metastatic breast cancer during pregnancy.Case: A 25-year-old woman was diagnosed with recurrent metastatic breast cancer during the second trimester of pregnancy. Tamoxifen was initially tried, however she had progression of her tumor markers, so was switched to a continuous infusion of 5-flurouracil (5-FU). She achieved a partial response and delivered a viable infant without congenital malformations.Conclusion: Many complex medical decisions occur when treating pregnant women with cancer. Infusional 5-FU was used successfully in this patient with no effect noted in the fetus. This regimen has not been previously described as treatment for recurrent breast cancer in pregnancy and should be considered.
Recurrent breast cancer; Pregnancy; Tamoxifen; 5-Flurouracil
Shiv E, Shank J, Richard J, Lutgendorf M, Oseni S, Gable P. Treatment of Recurrent Metastatic Breast Cancer in Pregnancy: A Case Report and Literature Review. Ann Clin Case Rep. 2017; 2: 1432.