Ann Clin Case Rep | Volume 2, Issue 1 | Case Report | Open Access

Treatment of a Myocardial Infiltrating Mediastinal Diffuse Large B-cell Lymphoma: A Case Report

Hassane Abdallah1*, Pier-Alexandre Vasil1, Gabriel Fortin2, Marianne Coutu1 and Sofia Marouan3

1Department of Cardiac Surgery, University of Sherbrooke, Canada
2 Department of Internal Medicine, University of Sherbrooke, Canada
3Department of Pathology, University of Sherbrooke, Canada

*Correspondance to: Hassane Abdallah 

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Background: Although primary cardiac lymphoma is rare and challenging to diagnose due to nonspecific symptoms, secondary one is more common, usually from the adjacent lung, breast, esophagus or thymus. However, very few cases describing the treatment of a myocardial infiltrating lymphoma are found in the literature.Case
Presentation: We report the case of a 28 year-old immunocompetent woman who presented with rapidly progressing heart failure symptoms with ischemic changes on her electrocardiogram. Different modalities of cardiac imaging showed a large mass compressing and infiltrating the right side of the heart. A biopsy was done and revealed the diagnosis of a B-cell lymphoma. She was treated accordingly with steroids and multi cycles of chemotherapy(R-EPOCH protocol), without any major adverse cardiac event.Conclusion: Although the risk of a myocardial rupture remains possible, we describe a case which demonstrates that a myocardial infiltrating lymphoma can safely be treated with standard chemotherapy regimens.


Diffuse large B-cell lymphoma; Myocardial infiltration; Heart rupture


Abdallah H, Vasil P-A, Fortin G, Coutu M, Marouan S. Treatment of a Myocardial Infiltrating Mediastinal Diffuse Large B-cell Lymphoma: A Case Report. Ann Clin Case Rep. 2017; 2: 1418.

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