Single Dose of Methotrexate Triggered Subacute Liver Failure in Patient with Adult Onset Still’s Disease

Huji Xu, Ting Li, Yaoyang Liu, Jian Yin, Ling Chen and Jing Song

Department of Rheumatology and Immunology, The second Military Medical University, China

^*Correspondance to: Huji Xu 

 PDF  Full Text Case Report | Open Access

Abstract:

Adult-onset Still disease (AOSD) is a rare systemic inflammatory condition of unknown origin. Treatment comprises non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppressive drugs including methotrexate (MTX). Low dose of MTX has been shown to be effective and well tolerated. Here, we present a 61-year-old male patient with AOSD developed subacute liver failure after a single dose of methotrexate. His subacute liver failure has been cured by high dosage of corticosteroid which also leads to serious complication, such as infection. To our knowledge, this is the first reported case of serious hepatotoxicity after a single dose of 10mg MTX in patient with AOSD.

Keywords:

Adult-onset still disease (AOSD); Herpes simplex virus (HSV); Human immunodeficiency virus (HIV)

Cite the Article:

Xu H, Li T, Liu Y, Yin J, Chen L, Song J. Single Dose of Methotrexate Triggered Subacute Liver Failure in Patient with Adult Onset Still′s Disease. Ann Clin Case Rep. 2016; 1: 1138.